FAM155B抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human heart tissue lysate, Primary antibody: P06494(FAM155B Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P06494(FAM155B Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P06494(FAM155B Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The FAM155B antibody is a research tool designed to detect and study the FAM155B protein, a member of the FAM155 (Family with sequence similarity 155) family. FAM155B, also known as TMEM86B, is a transmembrane protein encoded by the FAM155B gene located on human chromosome 12. While its precise biological function remains under investigation, FAM155B has been implicated in regulating neuronal excitability and calcium signaling through its interaction with voltage-gated calcium channels, particularly Cav3 T-type channels. Studies suggest it may modulate channel gating or trafficking, influencing cellular processes like neurotransmitter release and action potential firing.

FAM155B antibodies are typically developed for applications such as Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interactions in tissues or cultured cells. Research has explored its potential roles in neurological disorders, including epilepsy and neuropathic pain, where calcium channel dysregulation is implicated. Recent work also links FAM155B to cancer progression, with altered expression observed in certain malignancies.

Despite its emerging significance, FAM155B's molecular mechanisms and physiological relevance require further elucidation. Antibody validation remains critical due to sequence similarities with paralogs like FAM155A. Ongoing studies aim to clarify its structure-function relationships and therapeutic potential in channelopathies or other diseases.