SAXO2抗体—艾普蒂 新品

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     Western blot analysis using CDC2 mouse mAb against Jurkat (1) cell lysate.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human lung cancer (A) and esophageal cancer (B), showing cytoplasmic localization using CDC2 mouse mAb with DAB staining.    

  
  

The SAXO2 antibody is a research tool designed to target the SAXO2 (Stabilizer of Axonemal Microtubules 2) protein, which plays a critical role in maintaining the structural integrity and function of cilia and flagella. SAXO2 is part of a conserved protein family involved in stabilizing axonemal microtubules, essential components of motile cilia and flagella. These structures are vital for cellular motility, fluid movement, and sensory functions across various tissues. Dysregulation of ciliary proteins, including SAXO2. has been linked to ciliopathies—a group of genetic disorders affecting multiple organ systems, such as respiratory defects, infertility, and polycystic kidney disease.

SAXO2 antibodies are primarily used in biomedical research to investigate cilia biology, protein localization, and expression patterns in model organisms (e.g., mice, zebrafish) and human tissues. They enable techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize SAXO2 distribution and assess its interaction with other cytoskeletal components. Recent studies also explore SAXO2's potential role in cancer, as ciliary dysfunction may contribute to tumorigenesis. However, the antibody's specificity and application scope depend on rigorous validation, including knockout controls and epitope mapping. Ongoing research aims to clarify SAXO2's mechanistic contributions to cellular dynamics and disease pathways, highlighting its importance in both basic and translational studies.