PATJ抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P06483(PATJ Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The PATJ antibody targets the protein PATJ (Pals1-associated tight junction protein), a crucial component in maintaining cell polarity and tight junction integrity. Belonging to the membrane-associated guanylate kinase (MAGUK) family, PATJ contains multiple PDZ domains that mediate interactions with scaffolding proteins like PALS1 (CRB3 complex) and Par-3/Par-6/aPKC complexes. These interactions are essential for establishing apical-basal polarity in epithelial cells, regulating cell adhesion, and ensuring proper barrier function in tissues. PATJ is also implicated in Hippo and Notch signaling pathways, influencing cell proliferation and differentiation.

Research on PATJ has linked its dysfunction to various diseases, including cancers (e.g., glioblastoma, breast cancer) and neurological disorders (e.g., Alzheimer’s disease). Its role in epithelial-to-mesenchymal transition (EMT) underscores its importance in metastasis and tumor progression. PATJ antibodies are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to study protein localization, expression levels, and molecular interactions. These tools help unravel PATJ's regulatory mechanisms in tissue development, homeostasis, and disease pathogenesis, making it a focal point in studies of cell polarity and epithelial biology.