DDHD1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06360(DDHD1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P06360(DDHD1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of DDHD1 Antibody**

DDHD1 (Dual Domain HD-Containing Protein 1) is a phospholipase enzyme encoded by the *DDHD1* gene, belonging to the intracellular phospholipase A1 (PLA1) family. It plays a critical role in lipid metabolism, particularly in hydrolyzing phospholipids to generate bioactive lipid mediators. DDHD1 is implicated in membrane trafficking, organelle dynamics, and lipid droplet regulation, with prominent expression in the brain, testes, and liver.

Research links DDHD1 dysfunction to neurological disorders, including hereditary spastic paraplegia (HSP), a condition characterized by motor neuron degeneration. Mutations in *DDHD1* are associated with HSP subtype SPG28. highlighting its role in maintaining neuronal integrity. Additionally, DDHD1's involvement in lipid signaling pathways suggests potential connections to metabolic syndromes and cancer progression.

DDHD1 antibodies are essential tools for studying the protein's expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in investigations of its physiological and pathological roles. Commercial DDHD1 antibodies are typically developed against specific epitopes, often validated for specificity in knockout controls. Reliable antibodies help unravel DDHD1's interactions with lipid substrates, its regulatory mechanisms, and its contribution to disease pathways, offering insights for therapeutic targeting in lipid-related disorders.