LPIN1抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: NIH/3T3, K562 and HepG2 cell lysates, Primary antibody: P06328(LPIN1 Antibody) at dilution 1/850, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P06328(LPIN1 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of LPIN1 Antibody**

LPIN1 (Lipin-1) is a key protein encoded by the *LPIN1* gene, primarily involved in lipid metabolism and energy homeostasis. It functions as a phosphatidic acid phosphatase (PAP) enzyme, catalyzing the conversion of phosphatidic acid to diacylglycerol during triglyceride and phospholipid synthesis. Additionally, LPIN1 acts as a transcriptional co-regulator, interacting with nuclear receptors to modulate genes related to fatty acid oxidation and adipogenesis.

LPIN1 antibodies are essential tools for studying its roles in metabolic disorders, including obesity, insulin resistance, and lipodystrophy. Mutations in *LPIN1* are linked to recurrent rhabdomyolysis, a severe muscle condition, highlighting its clinical relevance. Researchers use LPIN1 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and post-translational modifications across tissues such as adipose, liver, and muscle.

These antibodies also aid in exploring LPIN1’s dual enzymatic and nuclear functions, particularly in models of metabolic syndrome or cancer, where altered lipid metabolism is a hallmark. Species-specific LPIN1 antibodies (e.g., human, mouse, rat) enable cross-species comparisons, supporting translational research. Validation of antibody specificity is critical due to homology with LPIN2/LPIN3 isoforms. Overall, LPIN1 antibodies are pivotal for dissecting molecular mechanisms in lipid biology and disease.