HOXA10抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cell lysate, Primary antibody: P06327(HOXA10 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P06327(HOXA10 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The HOXA10 antibody is a valuable tool for studying the HOXA10 protein, a member of the homeobox (HOX) gene family critical for embryonic development, axial patterning, and tissue differentiation. HOXA10. located on chromosome 7p15.2. encodes a transcription factor that regulates gene networks involved in morphogenesis, particularly in the reproductive system, hematopoietic stem cells, and limb development. It plays a key role in uterine receptivity during implantation, making it a focus in fertility and endometrial disorder research.

HOXA10 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression, localization, and dynamics in tissues or cell lines. These antibodies help investigate HOXA10's role in pathologies such as endometriosis, recurrent pregnancy loss, and cancers (e.g., leukemia, breast, and ovarian cancers), where dysregulated HOXA10 expression is linked to disease progression.

Researchers also utilize HOXA10 antibodies to explore epigenetic regulation, as HOXA10 expression can be modulated by DNA methylation or histone modifications. Commercial HOXA10 antibodies are typically raised against specific epitopes, often validated for cross-reactivity in humans, mice, or rats. Proper validation via knockout controls or siRNA knockdown is essential due to potential cross-reactivity with other HOX proteins. Overall, HOXA10 antibodies remain pivotal in developmental biology, oncology, and reproductive medicine research.