GHRHR抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06324(GHRHR Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The growth hormone-releasing hormone receptor (GHRHR) is a G protein-coupled receptor predominantly expressed in the anterior pituitary gland. It plays a critical role in the hypothalamic-pituitary-somatotroph axis by binding to growth hormone-releasing hormone (GHRH), triggering intracellular cAMP signaling that stimulates growth hormone (GH) synthesis and release. Dysregulation of GHRHR is linked to endocrine disorders, including GH deficiency or excess, and has been implicated in certain cancers due to its potential role in tumor cell proliferation.

GHRHR antibodies are essential tools for studying receptor expression, localization, and function in physiological and pathological contexts. They enable researchers to investigate GHRHR distribution in tissues, quantify expression levels via techniques like Western blotting or immunohistochemistry, and explore receptor activation mechanisms. In clinical research, these antibodies aid in diagnosing GH-related disorders and evaluating therapeutic targets. For instance, monoclonal antibodies against GHRHR have been explored for their potential to modulate GH secretion or block aberrant signaling in tumors. Recent studies also highlight their utility in understanding GHRHR mutations associated with familial short stature. As therapeutic agents, GHRHR antibodies remain experimental but hold promise for conditions like acromegaly or cancers overexpressing GHRHR, underscoring their dual role in basic research and translational medicine.