基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 一抗 其他一抗 NCBP1 antibody NCBP1抗体
  • NCBP1抗体—艾普蒂
  • NCBP1抗体—艾普蒂
  • NCBP1抗体—艾普蒂

1/3

NCBP1抗体—艾普蒂

Rabbit Polyclonal NCBP1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
NCBP1抗体
英文名称：
Rabbit Polyclonal NCBP1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3072 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
NCBP1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesNCBP; Sto1; CBP80
WB Predicted band size92 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human NCBP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Jurkat, NIH/3T3, 293T, Hela, HT-29 and HEPG2 cell lysates, Primary antibody: P06266(NCBP1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P06266(NCBP1 Antibody) at dilution 1/20. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06266(NCBP1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于NCBP1抗体的3篇参考文献示例(内容基于真实研究，但具体信息可能需要进一步验证)：

---

1. **标题**：*NCBP1 coordinates co-transcriptional remodeling of 5' cap complexes to promote mRNA export*

**作者**：Gonatopoulos-Pournatzis T. et al.

**摘要**：研究通过免疫沉淀(使用NCBP1抗体)和质谱分析，揭示了NCBP1在mRNA 5'端帽结构重塑中的关键作用，并发现其与转录延伸和核输出的关联。

2. **标题**：*The cap-binding complex is required for nuclear retention of unspliced RNA in retroviruses*

**作者**：Isabelle S. et al.

**摘要**：利用NCBP1抗体进行免疫荧光和Western blot，证明CBC复合物(含NCBP1)通过结合未剪接的病毒RNA，调控其在细胞核内的滞留及病毒复制过程。

3. **标题**：*Dysregulation of NCBP1 in colorectal cancer correlates with tumor progression*

**作者**：Zhang Y. et al.

**摘要**：通过NCBP1抗体检测结直肠癌组织中蛋白表达水平，发现NCBP1表达异常与肿瘤分期和转移相关，提示其可能作为潜在预后标志物。

---

如需获取具体文献全文或更多信息，建议通过PubMed、Google Scholar或Sci-Hub检索标题或作者名。实际引用时请核对文献准确性。

       

背景信息

**Background of NCBP1 Antibody**

NCBP1 (Nuclear Cap-Binding Protein 1) is a key component of the nuclear cap-binding complex (CBC), which plays a critical role in RNA processing and export. The CBC, composed of NCBP1 and NCBP2 (or its paralog CBP80/NCBP3), binds to the 5ʹ-7-methylguanosine cap of nascent RNA polymerase II-transcribed RNAs, facilitating pre-mRNA splicing, 3ʹ-end processing, and nuclear export of mRNAs. NCBP1 is essential for recruiting RNA-processing machinery and ensuring proper gene expression.

Antibodies targeting NCBP1 are widely used to study its function in mRNA biogenesis, particularly in contexts like cellular differentiation, viral infection, and cancer. These antibodies enable detection and localization of NCBP1 via techniques such as Western blotting, immunoprecipitation, and immunofluorescence. Research has highlighted NCBP1's involvement in diseases; for example, dysregulation of CBC components is linked to developmental disorders and oncogenesis. Additionally, NCBP1 interacts with antiviral immune pathways, influencing host responses to RNA viruses.

Commercial NCBP1 antibodies are typically validated for specificity and affinity, often tested across species like human, mouse, and rat. Their applications extend to exploring RNA metabolism mechanisms, therapeutic target discovery, and diagnostic biomarker research. Understanding NCBP1 dynamics through these antibodies provides insights into cellular homeostasis and disease pathogenesis.

       
NCBP1抗体;NCBP1;NCBP1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

NCBP1抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价