DNASE1L2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06262(DNASE1L2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P06262(DNASE1L2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The DNASE1L2 (Deoxyribonuclease 1-Like 2) antibody is a tool used to detect and study the DNASE1L2 protein, a member of the DNase I family. DNASE1L2 is a calcium/magnesium-dependent endonuclease implicated in DNA fragmentation during apoptosis and other physiological processes. Unlike its well-characterized homolog DNASE1 (DNase I), which primarily acts in extracellular DNA digestion, DNASE1L2 is thought to function intracellularly, possibly in nuclear or mitochondrial DNA degradation. Its expression has been linked to specific tissues, including the skin, where it may play a role in keratinocyte differentiation and epidermal homeostasis.

Antibodies targeting DNASE1L2 are utilized in research to explore its biological functions, subcellular localization, and involvement in diseases. For example, studies suggest DNASE1L2 dysregulation may contribute to pathologies such as autoimmune disorders, cancer progression, or impaired DNA clearance in apoptotic cells. These antibodies are commonly validated for applications like Western blotting, immunohistochemistry, or immunofluorescence, often with species specificity (e.g., human, mouse). Researchers also employ them to investigate post-translational modifications or interactions with other proteins, shedding light on regulatory mechanisms. However, cross-reactivity with other DNase family members remains a consideration, requiring careful experimental controls. Ongoing work aims to clarify DNASE1L2's precise roles and its potential as a therapeutic target or biomarker.