ADRA2A抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human left thymus tissue lysate, Primary antibody: P06242(ADRA2A Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06242(ADRA2A Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The ADRA2A antibody is a research tool designed to detect the alpha-2A adrenergic receptor (ADRA2A), a G protein-coupled receptor (GPCR) that plays a critical role in regulating neurotransmitter release and sympathetic nervous system activity. ADRA2A is one of three alpha-2 adrenergic receptor subtypes (A, B, C) encoded by distinct genes. It is predominantly expressed in the central nervous system, particularly in presynaptic neurons, where it acts as an autoreceptor to inhibit norepinephrine release through negative feedback. This receptor also modulates other neurotransmitters like serotonin and dopamine, influencing processes such as cognition, mood, and cardiovascular function.

Antibodies targeting ADRA2A are widely used in neuroscience and pharmacological studies to map receptor distribution in tissues, assess expression levels under pathological conditions, or validate gene-editing models. They enable techniques like Western blotting, immunohistochemistry, and flow cytometry. However, specificity challenges may arise due to structural similarities between adrenergic receptor subtypes, requiring careful validation via knockout controls or orthogonal methods.

Dysregulation of ADRA2A has been implicated in hypertension, attention-deficit/hyperactivity disorder (ADHD), depression, and neurodegenerative diseases. Research using ADRA2A antibodies has helped elucidate its role in drug mechanisms, such as the antihypertensive agent clonidine or the antidepressant mirtazapine, which target alpha-2 receptors. Ongoing studies explore its therapeutic potential in metabolic disorders and pain management, underscoring the antibody's utility in both basic and translational research.