REST抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P06226(REST Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

REST (RE1-Silencing Transcription Factor), also known as NRSF (Neuron-Restrictive Silencing Factor), is a transcriptional repressor critical for regulating neuron-specific genes in non-neuronal cells and neural progenitors. It binds to RE1 (Repressor Element 1) sequences, recruiting chromatin-modifying complexes to suppress neuronal differentiation genes, thereby maintaining cellular pluripotency or directing cell fate decisions. Dysregulation of REST is implicated in neurological disorders, cancers, and developmental defects. For instance, aberrant REST activity is observed in brain tumors, neurodevelopmental disorders, and neurodegenerative diseases like Alzheimer’s.

REST antibodies are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blot, immunohistochemistry, and ChIP-seq, helping researchers explore REST’s role in gene silencing, neural development, and disease mechanisms. Commercial REST antibodies are often validated for specificity against conserved epitopes, though isoforms and post-translational modifications (e.g., phosphorylation) can complicate detection. Studies using these antibodies have revealed REST’s dual roles in cancer—acting as a tumor suppressor in some contexts (e.g., medulloblastoma) and an oncogene in others (e.g., glioblastoma). Additionally, REST antibodies aid in investigating its interplay with non-coding RNAs and epigenetic regulators, advancing insights into neuroplasticity and therapeutic targeting.