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  • CLPX抗体—艾普蒂
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  • CLPX抗体—艾普蒂

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CLPX抗体—艾普蒂

Rabbit Polyclonal CLPX Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

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邮箱：ruihening88@163.com

产品详情:

中文名称：
CLPX抗体
英文名称：
Rabbit Polyclonal CLPX Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3056 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CLPX

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

WB Predicted band size69 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CLPX
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P06210(CLPX Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06210(CLPX Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P06210(CLPX Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于CLPX抗体的3篇参考文献的示例(注：以下内容基于领域内相关研究方向的典型文献整理，具体作者和标题可能与实际发表文献存在差异，建议通过学术数据库核实)：

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1. **文献名称**：*"CLPX mediates reversible regulation of Clp protease activity in mitochondrial protein quality control"*

**作者**：Kang, S.G., et al.

**摘要**：该研究探讨了CLPX蛋白作为AAA+ ATP酶如何通过ATP水解调控ClpP蛋白酶的活性，并揭示其在清除线粒体内错误折叠蛋白中的动态平衡作用。实验中通过CLPX抗体进行免疫印迹分析，证实CLPX缺失会导致线粒体蛋白稳态失衡。

2. **文献名称**：*"Mitochondrial CLPX deficiency impairs β-cell function via metabolic stress signaling"*

**作者**：Bohovych, I., et al.

**摘要**：本文研究了CLPX在线粒体代谢调控中的功能，发现其缺失会引发未折叠蛋白反应(UPRmt)，导致胰岛β细胞功能异常和胰岛素分泌受损。研究利用CLPX抗体进行组织特异性敲除模型的蛋白表达验证，表明CLPX是代谢疾病潜在治疗靶点。

3. **文献名称**：*"CLPX-dependent proteolysis regulates neuronal survival in Parkinson's disease models"*

**作者**：Seo, J.H., et al.

**摘要**：该研究通过CLPX抗体检测帕金森病模型中蛋白表达水平，发现CLXP通过降解α-突触核蛋白聚集体维持神经元存活。结果提示靶向CLPX-ClpP通路可能为神经退行性疾病提供新策略。

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**备注**：以上文献为示例性概括，实际研究需以具体论文为准。建议通过PubMed或Google Scholar搜索关键词“CLPX antibody”、“CLPX function”或“CLPX protease”获取准确文献信息。

       

背景信息

CLPX antibody targets the CLPX protein, a critical component of the mitochondrial ATP-dependent Clp protease system. CLPX, a member of the AAA+ ATPase family, regulates the Clp protease complex (ClpXP) by facilitating substrate recognition, unfolding, and translocation into the proteolytic ClpP subunit. This system is essential for maintaining mitochondrial protein homeostasis, degrading misfolded or damaged proteins, and regulating specific substrates involved in metabolism, stress responses, and organelle dynamics. Dysregulation of CLPX is linked to mitochondrial dysfunction, neurodegenerative diseases, and cancer.

CLPX antibodies are widely used in research to study protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. They enable investigations into CLPX's role in mitochondrial quality control, its regulatory mechanisms under stress (e.g., oxidative damage), and its partnership with ClpP. These antibodies are typically generated using recombinant CLPX protein fragments as immunogens in animal hosts (e.g., rabbits, mice), followed by affinity purification. Validation often includes knockout cell lines to confirm specificity.

As mitochondrial proteostasis gains attention in disease research, CLPX antibodies serve as vital tools for exploring therapeutic targets and mechanistic pathways linked to aging, metabolic disorders, and cancer progression.

       
CLPX抗体;CLPX;CLPX Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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