SLC7A1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06137(SLC7A1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

SLC7A1. also known as CAT-1 (cationic amino acid transporter 1), is a protein encoded by the *SLC7A1* gene and belongs to the solute carrier family 7. It functions as a high-affinity transporter of cationic amino acids, particularly L-arginine, across cell membranes. This transporter plays a critical role in nitric oxide synthesis by regulating arginine availability, impacting vascular function, immune response, and cell proliferation. Dysregulation of SLC7A1 has been linked to various diseases, including cancer, cardiovascular disorders, and immune dysfunction. In cancer, SLC7A1 overexpression is associated with tumor growth, angiogenesis, and chemotherapy resistance, while in cardiovascular contexts, it influences endothelial function and blood pressure regulation.

SLC7A1 antibodies are essential tools for detecting and quantifying the expression of this protein in research and diagnostic applications. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to study SLC7A1 localization, expression levels, and interactions in different tissues or disease models. Both polyclonal and monoclonal antibodies are available, often targeting specific epitopes within the protein's extracellular or intracellular domains. Validation of SLC7A1 antibodies typically includes testing in knockout cell lines or tissues to confirm specificity. Researchers utilize these antibodies to explore SLC7A1's role in metabolic pathways, drug resistance mechanisms, and as a potential therapeutic target. Proper antibody selection depends on the experimental design, species reactivity, and application requirements.