CNTNAP1抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, A172 cell, Hela cell lysates, Primary antibody: P06135(CNTNAP1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06135(CNTNAP1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P06135(CNTNAP1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The CNTNAP1 (Contactin Associated Protein 1) gene encodes a transmembrane protein belonging to the neurexin superfamily, which plays a critical role in nervous system development and function. CNTNAP1 is predominantly expressed in myelinated neurons, where it facilitates cell-cell interactions, axon-glia communication, and the formation of specialized membrane domains, such as the nodes of Ranvier. It interacts with contactin-1 (CNTN1) to stabilize these structures, ensuring efficient saltatory conduction of nerve impulses.

Antibodies targeting CNTNAP1 are essential tools in neuroscience research, enabling the study of its expression, localization, and molecular interactions. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize CNTNAP1 in neural tissues or cultured cells. Dysregulation of CNTNAP1 has been implicated in neurological disorders, including neuropathies and leukodystrophies. For example, homozygous mutations in CNTNAP1 are linked to severe hypomyelinating syndromes, underscoring its role in myelination.

Research-grade CNTNAP1 antibodies aid in elucidating disease mechanisms and validating animal models. However, specificity and validation remain critical due to potential cross-reactivity with structurally related proteins. Ongoing studies leverage these antibodies to explore therapeutic strategies targeting myelination defects, highlighting their translational relevance in neurodevelopmental and neurodegenerative conditions.