AKIP1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P06091(AKIP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

AKIP1 (A Kinase Interacting Protein 1) is a regulatory protein that interacts with protein kinase A (PKA), a key enzyme in cellular signaling pathways. It modulates PKA activity by influencing its subcellular localization and substrate specificity, particularly under stress conditions. AKIP1 is involved in critical processes such as cell survival, proliferation, and apoptosis, and has been implicated in pathways like NF-κB signaling. Its expression is notably upregulated in certain cancers, including breast and colorectal cancer, where it correlates with poor prognosis and therapeutic resistance.

AKIP1 antibodies are essential tools for studying its expression, localization, and functional roles. These antibodies enable detection of AKIP1 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. High-quality AKIP1 antibodies are validated for specificity, often using knockout cell lines to confirm minimal cross-reactivity. Researchers employ these antibodies to explore AKIP1's involvement in disease mechanisms, such as its role in promoting cancer metastasis or enhancing cardiomyocyte survival during ischemic stress.

The study of AKIP1 and its antibodies holds therapeutic potential, particularly in targeting cancer progression and improving cardiac outcomes. Ongoing research aims to elucidate its molecular interactions and regulatory networks, which may lead to novel biomarkers or therapeutic strategies in oncology and cardiovascular diseases.