CDC123抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T and Hela cell lysates, Primary antibody: P06088(CDC123 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

The CDC123 antibody targets the CDC123 protein, a conserved eukaryotic factor involved in cell cycle regulation and metabolic homeostasis. Initially identified through yeast genetic studies (as Cdc123p), human CDC123 is crucial for the assembly of the eukaryotic translation initiation factor 2 (eIF2), linking cell cycle progression to protein synthesis. It plays a role in G1/S transition and mitotic entry by regulating cyclin levels and coordinating nutrient availability with cell division.

CDC123 antibodies are typically monoclonal or polyclonal reagents developed in hosts like rabbits or mice, designed to detect endogenous CDC123 via techniques such as Western blotting, immunofluorescence, or immunohistochemistry. These tools have been instrumental in studying CDC123's expression patterns, which are upregulated in proliferating tissues and certain cancers, suggesting its potential as a biomarker for malignancy or therapeutic targeting.

Research using CDC123 antibodies has also explored its interaction with metabolic pathways, including mTOR signaling, and its implications in diseases beyond cancer, such as diabetes and neurodegenerative disorders. Commercial availability from suppliers like Abcam and Cell Signaling Technology has facilitated its use in both basic and translational research, though validation for specific applications (e.g., post-translational modifications) remains essential. Dysregulation of CDC123 is increasingly linked to pathologies involving disrupted proteostasis and cell cycle anomalies.