PRSS50抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P06078(PRSS50 Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06078(PRSS50 Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

The PRSS50 antibody targets the protein encoded by the PRSS50 gene (Protease, Serine 50), a member of the trypsin-like serine protease family. PRSS50. also known as Testisin or TESP5. is a glycosylphosphatidylinositol (GPI)-anchored cell membrane protein predominantly expressed in male germ cells, particularly during late spermatogenesis. It plays a role in sperm maturation, epididymal transit, and fertilization by modulating extracellular matrix interactions. Aberrant PRSS50 expression has been linked to reproductive disorders, including infertility, and is investigated in cancers like testicular and ovarian carcinomas due to its tumor-specific overexpression.

PRSS50 antibodies are essential tools for studying its localization, expression patterns, and functional mechanisms. They are used in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry. Commercial antibodies are typically raised against specific epitopes, often in rodents or rabbits, and validated for specificity via knockout controls. Research utilizing these antibodies aims to clarify PRSS50's physiological roles, its potential as a diagnostic biomarker, and its therapeutic relevance in targeting cancer cells. However, challenges persist in ensuring antibody specificity due to homology within the serine protease family. Recent studies also explore PRSS50's involvement in immune regulation, expanding its biomedical significance beyond reproductive biology.