SUN5抗体—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human left kidney cancer tissue lysate, Primary antibody: P06001(SUN5 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P06001(SUN5 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The SUN5 antibody is a research tool targeting the SUN5 protein, a member of the Sad1/UNC-84 (SUN) domain protein family. SUN proteins are integral components of the nuclear envelope, mediating connections between the nucleoskeleton and cytoskeleton. Specifically, SUN5 is localized to the inner nuclear membrane and interacts with KASH domain proteins to form LINC (Linker of Nucleoskeleton and Cytoskeleton) complexes, which facilitate nuclear positioning, mechanical signaling, and chromosomal organization.

SUN5 is particularly notable in reproductive biology, where it plays a critical role in spermiogenesis. It is highly expressed in the testes and is essential for sperm head-tail conjunction. Studies show that SUN5 mutations or dysregulation disrupt the formation of the head-tail coupling apparatus (HTCA), leading to acephalic spermatozoa and male infertility. This has positioned SUN5 as a biomarker for diagnosing certain forms of teratozoospermia.

The SUN5 antibody is widely used in immunofluorescence, Western blotting, and immunohistochemistry to study SUN5 expression, localization, and function in cellular and pathological contexts. Its applications extend to exploring nuclear envelope dynamics, spermatogenic defects, and potential links to broader nuclear envelope-associated disorders. As research continues, the SUN5 antibody remains vital for unraveling mechanisms underlying fertility and nuclear architecture.