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  • H3C1抗体—艾普蒂
  • H3C1抗体—艾普蒂
  • H3C1抗体—艾普蒂

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H3C1抗体—艾普蒂

Rabbit Polyclonal H3C1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
H3C1抗体
英文名称：
Rabbit Polyclonal H3C1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2991 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
H3C1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesH3/A; H3FA; HIST1H3A
WB Predicted band size15 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human H3C1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Hela,231,A549,293T and NIH/3T3 cell,Mouse liver tissue,HUVEC cell lysates, Primary antibody: P05970(H3C1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 70 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05970(H3C1 Antibody) at dilution 1/30. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05970(H3C1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于H3C1抗体的模拟参考文献示例(仅供参考，建议通过学术数据库获取真实文献)：

1. **文献名称**：*Histone H3.1 Antibody Characterization in Epigenetic Studies*

**作者**：Li, X. et al.

**摘要**：该研究验证了H3C1抗体在染色质免疫沉淀(ChIP)中的特异性，证明其能有效区分H3.1与其他组蛋白变体(如H3.3)，并应用于癌症细胞系中核小体动态分析。

2. **文献名称**：*Role of H3C1 in Cellular Differentiation Revealed by Antibody-Based Profiling*

**作者**：Smith, J. & Gonzalez, R.

**摘要**：通过H3C1抗体的免疫荧光和Western blot实验，揭示了H3.1在干细胞分化过程中染色质重塑的关键作用，及其与多能性基因沉默的关联。

3. **文献名称**：*Development of a Monoclonal Antibody Targeting Human H3C1 for Diagnostic Applications*

**作者**：Wang, Y. et al.

**摘要**：报道了一种新型H3C1单克隆抗体的开发，验证其在高通量测序和临床样本中的稳定性，提示其作为结直肠癌表观遗传标志物的潜力。

4. **文献名称**：*Cross-Reactivity Analysis of Commercial H3C1 Antibodies in Model Organisms*

**作者**：Kumar, S. et al.

**摘要**：系统性评估了市售H3C1抗体在小鼠、斑马鱼等模式生物中的交叉反应性，发现部分抗体存在非特异性结合，为跨物种研究提供筛选依据。

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**说明**：以上内容为模拟生成，实际文献需通过PubMed/Google Scholar以“H3C1 antibody”或“histone H3.1 antibody”等关键词检索。若研究H3C1的翻译后修饰(如甲基化)，建议细化关键词(如“H3K27me3 antibody”)。

       

背景信息

The H3C1 antibody targets histone H3.1. a core component of nucleosomes that package eukaryotic DNA into chromatin. Histone H3 exists in multiple variants, with H3.1 (encoded by genes like *H3C1* in humans) being a replication-dependent subtype predominantly expressed during the S phase of the cell cycle. It plays a critical role in maintaining chromatin structure and regulating gene expression through post-translational modifications (e.g., acetylation, methylation) that influence epigenetic signaling.

H3C1 antibodies are widely used in epigenetics research to investigate histone modification patterns, chromatin dynamics, and their implications in diseases like cancer. These antibodies enable techniques such as chromatin immunoprecipitation (ChIP), immunofluorescence, and Western blotting to study H3.1-specific interactions or modifications. Specificity is crucial, as H3.1 differs subtly from other variants (e.g., H3.3) in amino acid sequence and function. Validation often involves knockdown models or peptide competition assays to confirm minimal cross-reactivity.

Commercial H3C1 antibodies are typically raised in rabbits or mice using synthetic peptides corresponding to conserved regions of H3.1. Researchers rely on these tools to explore cell cycle-dependent chromatin remodeling, DNA repair mechanisms, and aberrant histone modification profiles in pathological states. Proper controls are essential to distinguish H3.1 from other histone isoforms in experimental workflows.

       
H3C1抗体;H3C1;H3C1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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