ZDHHC5抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and HT29 cell lysates, Primary antibody: P05959(ZDHHC5 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05959(ZDHHC5 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The ZDHHC5 antibody is a crucial tool in studying the ZDHHC5 protein, a member of the DHHC (Asp-His-His-Cys) family of palmitoyltransferases. These enzymes catalyze protein palmitoylation, a post-translational modification critical for membrane anchoring, trafficking, and functional regulation of substrate proteins. ZDHHC5. localized primarily in the plasma membrane and endosomes, has been implicated in diverse cellular processes, including cell adhesion, signal transduction, and viral entry. Its dysregulation is linked to cancers, neurological disorders, and cardiovascular diseases.

ZDHHC5 antibodies are widely used in research to detect protein expression, subcellular localization, and interaction partners via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Specificity and validation (e.g., knockout controls) are essential due to structural homology among DHHC family members. Recent studies highlight ZDHHC5's role in tumor progression, synaptic plasticity, and receptor stability (e.g., EGFR, integrins), making its antibody valuable for mechanistic investigations. Commercial antibodies are typically raised against unique epitopes, such as N-terminal or catalytic domains, with monoclonal and polyclonal variants available. Researchers prioritize antibodies validated in their experimental systems to ensure reliability, particularly when exploring ZDHHC5's therapeutic potential or biomarker utility in disease models.