EFNB1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05945(EFNB1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The EFNB1 antibody is a crucial tool for studying the ephrin-B1 protein, a member of the ephrin family that binds to Eph receptors to mediate cell-cell communication. Ephrin-B1 (encoded by the *EFNB1* gene) is a transmembrane ligand involved in developmental processes, tissue patterning, and angiogenesis. It plays roles in cell adhesion, migration, and boundary formation through bidirectional signaling with Eph receptors, influencing both the ligand-presenting ("forward" signaling) and receptor-expressing cells ("reverse" signaling). Dysregulation of EFNB1 is linked to cancer progression, vascular abnormalities, and neurological disorders.

EFNB1 antibodies are widely used in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and flow cytometry. They help elucidate EFNB1's role in tumor microenvironment modulation, metastasis, and vascular development. Some antibodies target specific domains (e.g., the extracellular Eph-binding region or intracellular signaling motifs) to study functional mechanisms or block receptor-ligand interactions. Monoclonal and polyclonal variants exist, with validation often including knockout cell lines or tissue models to ensure specificity.

As EFNB1 gains attention as a therapeutic target, these antibodies also support drug discovery efforts, such as evaluating inhibitors that disrupt EFNB1-Eph interactions in cancer or regenerative medicine. Researchers must consider antibody clonality, species reactivity, and application-specific validation to ensure reliable results.