MAGEB1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05903(MAGEB1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The MAGEB1 antibody targets a member of the melanoma-associated antigen (MAGE) family, a group of proteins initially identified for their expression in melanomas and restricted presence in normal tissues, primarily the testis and placenta. MAGEB1. located on the X chromosome, belongs to the type I MAGE subfamily, characterized by a conserved MAGE homology domain (MHD) involved in protein interactions. Normally silenced in somatic cells, MAGEB1 is aberrantly re-expressed in various cancers, including melanoma, lung, and hepatocellular carcinoma, making it a cancer-testis antigen (CTA) of interest for immunotherapy and diagnostics.

Research on MAGEB1 focuses on its role in tumorigenesis, with studies suggesting involvement in transcriptional regulation, cell cycle progression, and apoptosis evasion. Its restricted expression profile and immunogenicity position MAGEB1 as a potential biomarker for cancer detection and a target for T-cell-based therapies, such as CAR-T or cancer vaccines. Antibodies against MAGEB1 are critical tools for studying its expression patterns, validating diagnostic assays, and developing targeted therapies. However, challenges remain, including antigen heterogeneity across tumors and potential off-target effects due to low-level expression in some healthy tissues. Ongoing efforts aim to optimize MAGEB1-specific antibodies for improved sensitivity and specificity in both research and clinical applications.