HOXD10抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P05871(HOXD10 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P05871(HOXD10 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The HOXD10 antibody is a tool used in biomedical research to detect the HOXD10 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors containing a conserved DNA-binding homeodomain, critical for regulating embryonic development, cell differentiation, and tissue patterning. Specifically, HOXD10. located on chromosome 2q31-32. plays roles in limb development, neural tube closure, and organogenesis. Dysregulation of HOXD10 has been implicated in cancer, where it may act as a tumor suppressor or promoter depending on context. For example, reduced HOXD10 expression is linked to metastasis in breast, colorectal, and cervical cancers, while its overexpression correlates with progression in gliomas and hepatocellular carcinoma.

The HOXD10 antibody enables researchers to study its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available antibodies are typically raised against specific epitopes of the human HOXD10 protein, with validation in relevant cell lines or tissues. Understanding HOXD10's dual roles in development and disease highlights its potential as a diagnostic marker or therapeutic target, driving ongoing interest in reliable detection tools like this antibody. Proper controls, such as knockout validation, are essential to ensure specificity in experimental settings.