CXCL10抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P05837(CXCL10 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

CXCL10 (C-X-C motif chemokine ligand 10), also known as interferon-γ-inducible protein 10 (IP-10), is a small cytokine belonging to the CXC chemokine family. It is primarily produced by immune cells (e.g., monocytes, endothelial cells) and stromal cells in response to proinflammatory signals, particularly interferon-γ (IFN-γ). CXCL10 functions by binding to its receptor CXCR3. recruiting activated T cells, natural killer (NK) cells, and dendritic cells to sites of inflammation or infection. It plays critical roles in antiviral responses, autoimmune diseases, and tumor immunology.

CXCL10 antibodies are essential tools for detecting and quantifying this chemokine in research and diagnostics. They are widely used in techniques like ELISA, Western blotting, and immunohistochemistry to study CXCL10 expression patterns in diseases such as rheumatoid arthritis, multiple sclerosis, viral infections (e.g., COVID-19), and cancer. In cancer biology, CXCL10 exhibits dual roles: it can promote antitumor immunity by attracting effector T cells, but may also support angiogenesis and metastasis in certain contexts. Therapeutic antibodies targeting CXCL10 or its receptor are under investigation to modulate immune responses in autoimmune disorders or enhance immunotherapy efficacy. Due to its involvement in cytokine storms and chronic inflammation, CXCL10 is also explored as a biomarker for disease severity and treatment monitoring.