CUBN抗体—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05822(CUBN Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P05822(CUBN Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of CUBN Antibody**

Cubilin (CUBN), encoded by the *CUBN* gene, is a large transmembrane glycoprotein functioning as a multiligand endocytic receptor. Primarily expressed in polarized epithelia, such as the renal proximal tubules and small intestine, it plays critical roles in nutrient uptake (e.g., vitamin B12) and protein reabsorption. CUBN lacks transmembrane domains but anchors to cell membranes via interactions with megalin (LRP2) and the transmembrane protein AMN (amnionless), forming the cubam complex. This complex mediates ligand internalization via clathrin-coated pits.

CUBN antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. Dysregulation of CUBN is linked to Imerslund-Gräsbeck syndrome (IGS), a rare genetic disorder characterized by vitamin B12 deficiency and proteinuria, as well as chronic kidney disease (CKD) due to impaired protein reabsorption. In research, CUBN antibodies enable immunohistochemical detection in tissues, Western blot analysis, and investigation of renal and intestinal pathologies. They also aid in exploring CUBN’s role in drug transport, metabolic disorders, and cancer, where altered expression may influence disease progression. Species-specific CUBN antibodies (e.g., human, mouse) are widely utilized to dissect molecular mechanisms in model systems.