HOXA2抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal muscle tissue and PC-3 cell, Primary antibody: P05790(HOXA2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P05790(HOXA2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The HOXA2 antibody is a research tool used to detect and study the HOXA2 protein, a member of the homeobox (HOX) gene family critical in embryonic development. HOX genes encode transcription factors that regulate body patterning along the anterior-posterior axis, with HOXA2 specifically involved in craniofacial and hindbrain development. It plays a role in specifying segmental identity in the second pharyngeal arch, influencing structures like the hyoid bone, middle ear ossicles, and cranial nerves. Dysregulation of HOXA2 is linked to congenital malformations, hearing loss, and certain cancers.

HOXA2 antibodies are widely employed in techniques such as immunohistochemistry (IHC), Western blotting, and immunofluorescence to localize and quantify HOXA2 expression in tissues or cell lines. These antibodies help investigate its role in developmental pathways, neural crest cell migration, and disease mechanisms. Researchers also utilize them to explore HOXA2 interactions with signaling molecules (e.g., retinoic acid, FGF) or epigenetic regulators. Commercial HOXA2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the protein. Validation via knockout controls or siRNA knockdown is essential to ensure specificity. As HOXA2 research expands into regenerative medicine and oncology, its antibody remains vital for uncovering molecular insights into development and pathology.