HOXA3抗体—艾普蒂

The HOXA3 antibody is a crucial tool in developmental biology and oncology research, targeting the Homeobox protein Hox-A3 encoded by the HOXA3 gene. HOX genes, highly conserved across species, regulate embryonic patterning, cell differentiation, and organogenesis by controlling spatial-temporal gene expression. HOXA3. part of the HOXA cluster on chromosome 7. plays a pivotal role in anterior-posterior axis formation, particularly in pharyngeal arch development, neural crest cell migration, and thymus/thyroid organogenesis. Dysregulation of HOXA3 has been implicated in cancers (e.g., leukemia, breast cancer) and congenital disorders. The HOXA3 antibody, typically produced in rabbits or mice as monoclonal or polyclonal variants, enables detection of HOXA3 protein expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers utilize it to investigate HOXA3's roles in developmental abnormalities, cancer progression, and epigenetic regulation. Validation parameters include specificity checks using knockout controls and cross-reactivity assessments. Commercial antibodies often cite applications in formalin-fixed paraffin-embedded (FFPE) tissues and frozen sections, with molecular weight detection around ~37 kDa. Its utility spans basic developmental studies and clinical research exploring HOXA3 as a potential diagnostic or therapeutic target.