TMEM107抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05752(TMEM107 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TMEM107 antibody is a research tool designed to target the transmembrane protein 107 (TMEM107), a conserved ciliary protein implicated in cilia formation, signaling, and disease. TMEM107 localizes to the transition zone of primary cilia, where it plays a critical role in regulating ciliary composition and Sonic Hedgehog (Shh) signaling. Mutations in the TMEM107 gene are associated with ciliopathies, such as Joubert syndrome, Meckel-Gruber syndrome, and skeletal dysplasia, underscoring its importance in developmental processes.

Antibodies against TMEM107 are typically developed in rabbits or mice using synthetic peptides or recombinant protein fragments as immunogens. These antibodies are validated for applications like Western blotting, immunofluorescence, and immunohistochemistry to study TMEM107 expression, subcellular localization, and interactions with ciliary complexes (e.g., CPLANE proteins). Researchers also use TMEM107 antibodies to investigate disease mechanisms in ciliopathy models or to assess tissue-specific protein dysregulation.

Recent studies highlight TMEM107's role in ciliary gatekeeping and its functional interplay with other ciliopathy-associated proteins (e.g., TMEM231. TMEM67). As cilia research expands, TMEM107 antibodies remain vital for dissecting ciliary biology and exploring therapeutic targets for ciliopathies. Commercial sources often provide species reactivity (human, mouse, rat) and specificity data via knockout validation to ensure reliability.