MTNR1B抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05706(MTNR1B Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P05706(MTNR1B Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The MTNR1B (melatonin receptor 1B) gene encodes a G protein-coupled receptor that binds melatonin, a hormone regulating circadian rhythms and metabolic processes. Primarily expressed in pancreatic islets, retina, and brain, MTNR1B mediates melatonin's effects on glucose homeostasis and insulin secretion. Genetic variations in MTNR1B, particularly the rs10830963 SNP, are strongly associated with type 2 diabetes and impaired fasting glucose, likely through altered receptor expression or signaling that disrupts β-cell function.

MTNR1B antibodies are essential tools for studying receptor localization, expression patterns, and molecular mechanisms in metabolic diseases. Researchers use these antibodies in techniques like immunohistochemistry, Western blotting, and flow cytometry to investigate MTNR1B's role in melatonin signaling pathways involving cAMP inhibition and kinase activation. Recent studies focus on its dual impact on circadian regulation and metabolic disorders, exploring therapeutic potential in diabetes management and sleep-related metabolic syndromes. Commercial MTNR1B antibodies are typically validated for specificity against human/mouse isoforms, enabling cross-species comparative studies. Challenges remain in clarifying its tissue-specific signaling cascades and developing targeted modulators for clinical applications.