MAFA抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse muscle tissue, Primary antibody: P05693(MAFA Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05693(MAFA Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05693(MAFA Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

MAFA (Musculoaponeurotic Fibrosarcoma Oncogene Homolog A) is a transcription factor belonging to the Maf family, which regulates gene expression by binding to specific DNA sequences. It plays a critical role in cellular differentiation, development, and function, particularly in pancreatic β-cells and ocular tissues. In pancreatic β-cells, MAFA is essential for maintaining glucose homeostasis by controlling insulin transcription and secretion. Its expression is tightly linked to β-cell maturation and function, with dysregulation implicated in diabetes mellitus. Reduced MAFA levels are observed in type 1 and type 2 diabetes, contributing to impaired insulin production. In the eye, MAFA is involved in lens fiber cell differentiation and crystallin gene regulation.

MAFA antibodies are vital tools for detecting and studying MAFA protein expression, localization, and interactions in research. They enable investigations into β-cell dysfunction, diabetes pathogenesis, and lens development abnormalities. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess MAFA levels in tissue samples or *in vitro* models. Additionally, MAFA's oncogenic potential in certain cancers has spurred interest in its role in tumorigenesis, with antibodies aiding in exploring its regulatory mechanisms. By facilitating MAFA-related research, these antibodies contribute to understanding metabolic disorders, developmental biology, and cancer, offering potential therapeutic insights.