FOXG1 抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue , Primary antibody: P05649(FOXG1  Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05649(FOXG1  Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

FOXG1 antibodies are essential tools in neuroscience and developmental biology research, targeting the FOXG1 protein encoded by the *FOXG1* gene. FOXG1. a member of the Forkhead box (FOX) transcription factor family, plays a critical role in forebrain development, neurogenesis, and cortical patterning during embryogenesis. It regulates the proliferation and differentiation of neural progenitor cells, and its dysfunction is linked to FOXG1 syndrome, a severe neurodevelopmental disorder characterized by intellectual disability, motor delays, and autism-like features. Mutations in *FOXG1* can cause haploinsufficiency or altered protein function, making the study of its expression and localization crucial.

FOXG1 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and chromatin immunoprecipitation (ChIP) to detect protein levels, tissue distribution, and DNA-binding activity. These antibodies help researchers investigate FOXG1's role in brain development, neuronal connectivity, and disease mechanisms. Commercial FOXG1 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and are validated for specificity across human, mouse, and rat models. Both monoclonal and polyclonal variants exist, with monoclonal antibodies offering higher consistency and polyclonals providing broader epitope recognition. Proper validation via knockout controls or siRNA knockdown is critical to ensure antibody reliability. Understanding FOXG1 dynamics through these tools advances insights into neurodevelopmental disorders and potential therapeutic strategies.