基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 IL18RAP抗体 IL18RAP抗体
  • IL18RAP抗体—艾普蒂
  • IL18RAP抗体—艾普蒂
  • IL18RAP抗体—艾普蒂

1/3

IL18RAP抗体—艾普蒂

Rabbit Polyclonal IL18RAP Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
IL18RAP抗体
英文名称：
Rabbit Polyclonal IL18RAP Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2908 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
IL18RAP

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
WB Predicted band size68 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human IL18RAP
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cell, Mouse spleen tissue lysates, Primary antibody: P05638(IL18RAP Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05638(IL18RAP Antibody) at dilution 1/50. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P05638(IL18RAP Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于IL18RAP抗体的3篇参考文献及其摘要概括：

---

1. **文献名称**: *IL-18 Receptor Accessory Protein-Mediated Signal Transduction*

**作者**: Born TL et al.

**摘要内容**: 本研究揭示了IL18RAP在IL-18信号通路中的关键作用，通过抗体阻断实验证实其作为辅助受体与IL-18Rα结合，激活下游NF-κB和MAPK通路，促进炎症反应。

2. **文献名称**: *Genetic and Functional Analysis of IL18RAP in Inflammatory Diseases*

**作者**: Thomassen E et al.

**摘要内容**: 文章通过全基因组关联分析(GWAS)发现IL18RAP基因多态性与类风湿性关节炎和克罗恩病相关，并利用特异性抗体抑制IL18RAP功能，证明其调控Th1细胞分化和炎症因子释放。

3. **文献名称**: *Structural Insights into IL-18 Receptor Complex by Cryo-EM*

**作者**: Zhang Y et al.

**摘要内容**: 利用冷冻电镜技术解析了IL-18与其受体IL-18Rα及辅助蛋白IL18RAP的三元复合物结构，基于抗体标记技术揭示了IL18RAP的构象变化对信号转导的调控机制。

---

注：以上文献为示例，实际引用时需核实具体期刊及作者信息。如需更多文献，可进一步限定研究领域(如肿瘤、自身免疫病等)。

       

背景信息

The IL18RAP (Interleukin-18 Receptor Accessory Protein) antibody targets a key component of the interleukin-18 (IL-18) signaling pathway. IL18RAP is a transmembrane protein that forms a heterodimeric receptor complex with IL-18Rα (IL1RL1) to mediate IL-18 signaling. This cytokine receptor plays a critical role in regulating innate and adaptive immune responses, particularly in promoting Th1 cell differentiation, enhancing NK cell activity, and driving inflammatory cascades. IL-18 itself is implicated in autoimmune diseases, chronic inflammation, and cancer.

Antibodies against IL18RAP are primarily used in research to study the receptor's expression, function, and interaction with IL-18. They enable detection of IL18RAP in immune cells via techniques like flow cytometry, immunohistochemistry, or Western blotting. Dysregulated IL-18 signaling, linked to altered IL18RAP expression, has been observed in conditions such as rheumatoid arthritis, inflammatory bowel disease, and certain cancers. Therapeutic strategies targeting IL-18/IL18RAP signaling, including neutralizing antibodies, are under investigation to modulate excessive inflammation. Recent studies also explore IL18RAP as a potential biomarker for disease severity or treatment response. However, the therapeutic application of IL18RAP antibodies remains experimental, requiring further validation of their efficacy and safety in clinical settings.

       
IL18RAP抗体;IL18RAP;IL18RAP Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

IL18RAP抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价