ACVRL1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: P05622(ACVRL1 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P05622(ACVRL1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05622(ACVRL1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

ACVRL1 (Activin Receptor-Like Kinase 1), also known as ALK1. is a transmembrane serine/threonine kinase receptor belonging to the TGF-β (transforming growth factor-beta) superfamily. It primarily binds ligands such as BMP9 (bone morphogenetic protein 9) and BMP10. playing a critical role in angiogenesis, vascular development, and maintaining endothelial cell homeostasis. Mutations in the ACVRL1 gene are linked to hereditary hemorrhagic telangiectasia (HHT) type 2. a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding.

ACVRL1 antibodies are immunological tools designed to detect and study the expression, localization, and function of the ACVRL1 protein in research and diagnostic contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate vascular biology, tumor angiogenesis, and HHT-related mechanisms. They help researchers understand ACVRL1's signaling pathways, including its interaction with BMP ligands and downstream Smad proteins, as well as its crosstalk with other receptors like endoglin. Commercial ACVRL1 antibodies are typically validated for specificity in human, mouse, or rat samples, aiding in both basic research and preclinical studies targeting vascular diseases or anti-angiogenic therapies.