GJB5抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: P05612(GJB5 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

GJB5 antibody targets the gap junction protein beta-5 (GJB5), encoded by the GJB5 gene, which belongs to the connexin family. Connexins form gap junctions, intercellular channels facilitating direct communication between adjacent cells by allowing the transfer of ions, metabolites, and signaling molecules. GJB5. also known as connexin 31.3 (Cx31.3), is a transmembrane protein with four domains, playing roles in cell proliferation, differentiation, and tissue homeostasis. It is predominantly expressed in epithelial tissues, skin, and the peripheral nervous system.

Mutations in GJB5 have been linked to skin disorders, such as erythrokeratodermia variabilis, and peripheral neuropathy. Research on GJB5 antibodies focuses on elucidating its physiological and pathological roles, particularly in dermatological and neurological conditions. These antibodies are essential tools for detecting GJB5 expression via techniques like immunohistochemistry, Western blotting, or immunofluorescence, aiding in the study of protein localization and function.

Additionally, GJB5 antibodies contribute to understanding disease mechanisms, such as impaired cell-cell communication in hereditary skin diseases or nerve dysfunction. Their development and validation are critical for diagnostic applications and exploring therapeutic strategies targeting connexin-related pathways. Ongoing studies aim to clarify structure-function relationships and interactions with other connexins, providing insights into tissue-specific gap junction networks.