AQP11抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05588(AQP11 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

Aquaporin-11 (AQP11) is a member of the aquaporin family, a group of transmembrane channel proteins that facilitate water and small solute transport across cellular membranes. Unlike classical aquaporins (AQP1-AQP10), AQP11 belongs to the "superaquaporin" or "unorthodox" subfamily (AQP11-AQP12) due to its distinct structural features, including a unique NPA motif (asparagine-proline-alanine) critical for channel function. AQP11 is primarily localized in intracellular membranes, such as the endoplasmic reticulum and mitochondria, suggesting roles in regulating intracellular water homeostasis, organelle volume, and metabolic processes. Studies in mice have linked AQP11 deficiency to renal dysfunction, polycystic kidneys, and cell vacuolation, highlighting its importance in cellular osmoregulation and organ health.

Antibodies targeting AQP11 are essential tools for investigating its expression, localization, and function. These antibodies are typically developed using immunogenic peptides or recombinant protein fragments and validated via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Due to AQP11's intracellular localization, effective antibody detection often requires optimized tissue fixation and permeabilization protocols. Commercial AQP11 antibodies are widely used in research on kidney diseases, metabolic disorders, and cancer, where AQP11 dysregulation has been implicated. However, researchers must verify antibody specificity using knockout controls, as cross-reactivity with other aquaporins or proteins remains a potential challenge. Ongoing studies aim to clarify AQP11's mechanistic roles and therapeutic potential in human diseases.