ZNF146抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P05570(ZNF146 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

ZNF146 (Zinc Finger Protein 146), also known as OZF or ZKSCAN14. is a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. These proteins typically function as transcriptional regulators, often involved in chromatin remodeling and gene expression control through interactions with specific DNA sequences. ZNF146 contains multiple C2H2-type zinc finger motifs and a KRAB domain, which mediates protein-protein interactions, particularly with co-repressors like KAP1/TIF1β to recruit histone-modifying complexes for transcriptional repression.

Antibodies targeting ZNF146 are essential tools for studying its expression, localization, and molecular interactions. Research has linked ZNF146 to diverse cellular processes, including DNA damage response, cell cycle regulation, and oncogenesis. It interacts with PARP-1 (poly-ADP-ribose polymerase 1), suggesting a role in DNA repair pathways. Additionally, ZNF146 overexpression has been observed in certain cancers, such as hepatocellular carcinoma and breast cancer, where it may promote tumor progression by modulating cell proliferation or apoptosis-related genes.

Commercial ZNF146 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in cell lines and tissue samples. Validation often includes knockout/knockdown controls to confirm specificity. Studies using these antibodies have helped elucidate ZNF146's nuclear localization and its dynamic expression during cell stress or differentiation. Ongoing research aims to clarify its precise mechanistic roles and potential as a therapeutic target, particularly in cancer biology and genome stability maintenance.