ZBTB2抗体—艾普蒂

The ZBTB2 antibody is a research tool designed to detect and study the ZBTB2 protein, a member of the zinc finger and BTB domain-containing (ZBTB) family. ZBTB2 functions as a transcriptional repressor involved in regulating gene expression by binding to specific DNA sequences. It contains a BTB/POZ domain for protein-protein interactions and zinc finger motifs for DNA binding. Studies suggest ZBTB2 plays roles in cell cycle regulation, apoptosis, and cancer progression by modulating pathways such as the p53 tumor suppressor network. Its overexpression has been linked to tumorigenesis in certain cancers, potentially through repressing p53 target genes. Researchers use ZBTB2 antibodies in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to investigate its expression patterns, subcellular localization, and interactions with other proteins or DNA elements. These studies aim to clarify ZBTB2's biological functions, its regulatory mechanisms in cellular processes, and its potential as a therapeutic target. Commercial ZBTB2 antibodies are typically validated for specificity across human, mouse, and rat samples, supporting research in oncology, epigenetics, and cell proliferation studies.