HMGCLL1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue and Human fetal brain tissue lysates, Primary antibody: P03104(HMGCLL1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03104(HMGCLL1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P03104(HMGCLL1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The HMGCLL1 (3-Hydroxy-3-Methylglutaryl-CoA Lyase-Like 1) antibody is designed to detect the HMGCLL1 protein, a member of the HMG-CoA lyase family. HMGCLL1 shares structural homology with HMGCL, a mitochondrial enzyme critical for ketogenesis and leucine metabolism, but lacks conserved catalytic residues, suggesting divergent functions. While HMGCL cleaves HMG-CoA into acetyl-CoA and acetoacetate, HMGCLL1’s exact biochemical role remains unclear. Studies indicate it may localize to the cytoplasm and nucleus, implicating potential roles in cellular processes beyond metabolism, such as transcriptional regulation or cell signaling.

HMGCLL1 is expressed in various tissues, with elevated levels observed in certain cancers, including hepatocellular carcinoma and breast cancer, suggesting its possible involvement in tumorigenesis or progression. The antibody is widely used in research to investigate HMGCLL1’s expression patterns, subcellular localization, and disease associations. Common applications include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validated antibodies typically target specific epitopes, ensuring specificity for HMGCLL1 over homologous proteins like HMGCL. Researchers utilize these tools to explore HMGCLL1’s functional significance, particularly its potential as a biomarker or therapeutic target in metabolic disorders and oncology. Further studies are needed to fully elucidate its biological mechanisms and clinical relevance.