GIMAP2抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: HT-29, K562 and HUVEC cell lysates, Primary antibody: P03103(GIMAP2 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 6 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P03103(GIMAP2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

GIMAP2 (GTPase of the immunity-associated protein 2) is a member of the GIMAP family, a group of GTP-binding proteins predominantly expressed in immune cells, particularly lymphocytes. These proteins are evolutionarily conserved and play critical roles in immune system regulation, including lymphocyte survival, differentiation, and homeostasis. GIMAP2 is encoded by the *GIMAP2* gene located within the human chromosomal region 7q36.1. a region linked to autoimmune and inflammatory disorders. Structurally, it contains a conserved GTP-binding domain, suggesting its involvement in intracellular signaling or vesicular trafficking processes.

Antibodies targeting GIMAP2 are essential tools for studying its expression, localization, and function. Research indicates that GIMAP2 may influence T-cell development and apoptosis, with potential implications in autoimmune diseases, immunodeficiency, and cancer. For instance, altered GIMAP2 expression has been observed in conditions like rheumatoid arthritis and leukemia. However, its precise mechanistic roles remain unclear, partly due to functional redundancy among GIMAP family members. Commercial GIMAP2 antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and flow cytometry. Challenges in antibody development include ensuring specificity due to high homology within the GIMAP family. Ongoing studies aim to clarify GIMAP2's interactions with other immune regulators and its therapeutic potential in modulating immune responses.