KCNE3抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03074(KCNE3 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of KCNE3 Antibody**

KCNE3. a member of the KCNE family of voltage-gated potassium (Kv) channel regulatory subunits, is a small transmembrane protein that modulates the function of potassium channels such as KCNQ1. It plays a critical role in regulating cardiac and muscle excitability, ion transport, and cellular electrical signaling. KCNE3 antibodies are immunological tools designed to detect and study the expression, localization, and functional interactions of KCNE3 in research and diagnostic contexts.

These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate KCNE3's involvement in physiological and pathological processes. For instance, KCNE3 dysfunction has been linked to cardiac arrhythmias, skeletal muscle disorders, and inherited conditions like hypokalemic periodic paralysis. Researchers employ KCNE3 antibodies to explore its regulatory mechanisms in Kv channel complexes, its tissue-specific distribution, and its role in disease pathogenesis.

Monoclonal and polyclonal KCNE3 antibodies are generated using immunogenic peptide sequences, often validated for specificity and cross-reactivity. Their applications extend to drug discovery, where they help assess therapeutic targeting of potassium channels. Overall, KCNE3 antibodies serve as essential reagents for advancing understanding of ion channel biology and related disorders.