HCCS抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HepG2 cell, Mouse heart tissue lysates, Primary antibody: P03069(HCCS Antibody) at dilution 1/4000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P03069(HCCS Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of HCCS Antibody**

HCCS (Holocytochrome C Synthase) is a mitochondrial enzyme critical for heme attachment during the maturation of cytochrome c, a key component in the electron transport chain and apoptosis. HCCS catalyzes the covalent linkage of heme to apocytochrome c, enabling cytochrome c’s functional role in cellular energy production and programmed cell death. Dysregulation of HCCS is linked to mitochondrial disorders, cancer, and diseases involving apoptotic defects.

HCCS antibodies are immunological tools designed to detect and quantify HCCS protein levels in research settings. These antibodies are typically developed using recombinant HCCS protein or peptide immunogens, validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Their utility spans studies on mitochondrial function, cancer metabolism (e.g., tumors with altered cytochrome c dynamics), and developmental disorders, such as microphthalmia with linear skin defects (MLS) syndrome, linked to HCCS mutations.

Recent research highlights HCCS's role beyond cytochrome c maturation, including potential involvement in redox signaling and cellular stress responses. Antibodies targeting HCCS thus serve as essential reagents for unraveling its molecular mechanisms in health and disease, offering insights into therapeutic strategies for mitochondrial pathologies and cancers.