MRPS35抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: LOVO, K562, Jurkat and Hela cell lysates, Primary antibody: P03057(MRPS35 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03057(MRPS35 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of MRPS35 Antibody**

The MRPS35 (Mitochondrial Ribosomal Protein S35) antibody is a research tool designed to detect and study the MRPS35 protein, a component of the mitochondrial ribosome's small subunit (28S). Mitochondrial ribosomes are essential for synthesizing proteins encoded by mitochondrial DNA, particularly those involved in oxidative phosphorylation (OXPHOS), a critical pathway for cellular energy production. MRPS35 plays a structural and functional role in maintaining ribosome integrity and facilitating translation within mitochondria.

Interest in MRPS35 stems from its potential involvement in mitochondrial dysfunction-linked diseases, including neurodegenerative disorders, metabolic syndromes, and cancer. Dysregulation of mitochondrial protein synthesis has been implicated in impaired cellular energetics and apoptosis. Researchers utilize MRPS35 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate protein expression levels, subcellular localization, and mitochondrial health in disease models.

Commercial MRPS35 antibodies are typically raised against specific epitopes, often recombinant proteins or synthetic peptides. Validation includes testing in knockdown/knockout models to confirm specificity. Recent studies also explore MRPS35's role in cancer progression, as altered mitochondrial metabolism is a hallmark of tumorigenesis. Understanding MRPS35's function through antibody-based assays may reveal therapeutic targets for mitochondrial disorders or strategies to modulate cellular energy metabolism in pathological conditions.