DNAJC12抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: RAW264.7, 293T cell lysates, Primary antibody: P03035(DNAJC12 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P03035(DNAJC12 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of DNAJC12 Antibody**

DNAJC12. a member of the HSP40/DNAJ chaperone family, functions as a co-chaperone for HSP70 proteins, aiding in cellular protein folding, stability, and degradation. It plays critical roles in neurotransmitter synthesis by regulating enzymes like tyrosine hydroxylase and tryptophan hydroxylase, which are essential for dopamine and serotonin production. Dysregulation of DNAJC12 is linked to neurological disorders, including early-onset parkinsonism, dystonia, and neurodevelopmental deficits.

DNAJC12 antibodies are valuable tools in studying its expression, localization, and interactions in cellular and disease contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping to elucidate DNAJC12's role in protein quality control, stress responses, and neural homeostasis. Recent research also explores its potential involvement in cancer, where chaperone systems are often hijacked to support tumor progression.

By targeting DNAJC12. these antibodies contribute to understanding molecular mechanisms underlying neurodegenerative diseases and cancer, offering insights for therapeutic strategies. Their specificity ensures accurate assessment of DNAJC12 levels in pathological tissues, aiding biomarker discovery and mechanistic studies.