TBPL1抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P03027(TBPL1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P03027(TBPL1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P03027(TBPL1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The TBPL1 antibody is a crucial tool for studying the TATA-binding protein-like 1 (TBPL1), a transcription factor involved in regulating gene expression. TBPL1. also known as TRF3 or TBP2. is a paralog of the TATA-binding protein (TBP) and plays distinct roles in transcriptional initiation, particularly during early development and cellular differentiation. Unlike TBP, which is ubiquitously expressed, TBPL1 is predominantly active in oocytes, early embryos, and certain somatic cells, suggesting specialized regulatory functions in gametogenesis and embryogenesis.

Structurally, TBPL1 shares a conserved DNA-binding domain with TBP but differs in its N-terminal region, which may influence promoter selectivity or interactions with other transcription factors. Research highlights its role in binding TATA-less promoters and facilitating RNA polymerase II recruitment, indicating unique mechanisms in gene activation.

TBPL1 antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect TBPL1 expression, localization, and protein-protein interactions. These studies are vital for unraveling its contributions to developmental processes, such as zygotic genome activation, and its potential dysregulation in reproductive disorders or cancers.

Recent studies also explore TBPL1's evolutionary conservation across vertebrates and its interplay with other transcription regulators, emphasizing its importance in maintaining cellular identity and developmental timing. The availability of specific TBPL1 antibodies continues to advance molecular and developmental biology research, offering insights into transcriptional diversity and disease mechanisms.