PDAP1抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 231 cell, 293T cell and Rat brain tissue lysates, Primary antibody: P03022(PDAP1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P03022(PDAP1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The PDAP1 (Phosphatase Domain Associated Protein 1) antibody is a tool used to study the PDAP1 protein, encoded by the *PDAP1* gene in humans. PDAP1 is a conserved, ubiquitously expressed protein implicated in cell proliferation, apoptosis, and stress responses. It interacts with protein tyrosine phosphatases (PTPs), such as PTEN, and modulates their activity, suggesting a role in regulating signaling pathways like PI3K/AKT, which are critical for cell survival and growth. PDAP1 also associates with microtubules, influencing cytoskeletal dynamics and intracellular trafficking.

Research highlights PDAP1's dual role in cancer: it may act as an oncogene or tumor suppressor depending on context. Elevated PDAP1 expression correlates with poor prognosis in certain cancers (e.g., gliomas), while its downregulation is linked to others (e.g., colorectal cancer). PDAP1 antibodies are essential for detecting protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate PDAP1's localization, interaction partners, and mechanistic contributions to diseases, offering insights into therapeutic targeting. Commercial PDAP1 antibodies are typically raised against specific epitopes (e.g., human PDAP1 N-terminal regions) and validated for specificity in diverse experimental models. Ongoing studies aim to clarify PDAP1's regulatory networks and clinical relevance in oncology and beyond.