GSKIP抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P02990(GSKIP Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

**Background of GSKIP Antibody**

GSKIP (Glycogen Synthase Kinase 3β Interaction Protein) is a regulatory protein that interacts with GSK3β, a key kinase in the Wnt/β-catenin signaling pathway. Discovered in the early 2000s, GSKIP acts as a scaffold protein, modulating GSK3β activity and its downstream targets, including β-catenin. GSK3β is involved in diverse cellular processes, such as metabolism, differentiation, and apoptosis, but its dysregulation is linked to cancers, neurodegenerative diseases, and diabetes.

GSKIP’s interaction with GSK3β can either inhibit or enhance its kinase activity, depending on cellular context, thereby influencing β-catenin stability and Wnt signaling outcomes. Studies highlight GSKIP’s dual role: it may suppress tumor growth by promoting β-catenin degradation or contribute to oncogenesis by facilitating Wnt pathway activation.

Antibodies targeting GSKIP are critical tools for studying its expression, localization, and function. They enable detection via Western blotting, immunofluorescence, and immunoprecipitation, aiding research into GSKIP’s mechanistic roles in development and disease. Recent work explores GSKIP as a potential therapeutic target, particularly in cancers with aberrant Wnt signaling. However, its precise regulatory mechanisms remain under investigation, necessitating further exploration using validated GSKIP-specific antibodies.