GPSM1抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebrum tissue and Mouse brain tissue lysates, Primary antibody: P02908(GPSM1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P02908(GPSM1 Antibody) at dilution 1/85. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P02908(GPSM1 Antibody) at dilution 1/85. (Original magnification: ×200)    

  
  

The GPSM1 antibody targets the G Protein Signaling Modulator 1 (GPSM1), also known as Activator of G-protein Signaling 3 (AGS3). This protein is a member of the AGS family, which regulates G-protein-coupled receptor (GPCR) signaling by interacting with Gα subunits. GPSM1 contains conserved GoLoco motifs that enable binding to inactive Gαi/o proteins, modulating their activity and influencing downstream cellular processes such as cell division, polarity establishment, and asymmetric cell fate determination. It plays a critical role in mitotic spindle orientation during development, particularly in neurogenesis and epithelial tissue organization.

Research links GPSM1 dysregulation to neurological disorders, cancer, and developmental abnormalities. For instance, altered GPSM1 expression has been observed in breast cancer, hepatocellular carcinoma, and neuropsychiatric conditions. The GPSM1 antibody is widely used in molecular biology to study these mechanisms through techniques like Western blotting, immunofluorescence, and immunohistochemistry. It helps identify protein localization, expression levels, and interactions in cellular models or tissue samples, aiding in the exploration of GPSM1's role in disease pathogenesis and potential therapeutic targeting. Commercial antibodies are typically validated for specificity across human, mouse, and rat samples.