NIPSNAP3A抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P02870(NIPSNAP3A Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The NIPSNAP3A antibody is a tool used to detect the NIPSNAP3A protein, a member of the NipSnap (4-nitrophenylphosphatase domain and non-neuronal SNAP25-like) family. NIPSNAP3A, encoded by the *NIPSNAP3A* gene in humans, is a mitochondrial protein implicated in diverse cellular processes, including mitophagy, energy metabolism, and intracellular trafficking. Structurally, it contains a conserved NIPSNAP domain critical for protein-protein interactions. Studies suggest its role in mitochondrial quality control by recruiting autophagy receptors like OPTN and TAX1BP1 during stress, facilitating damaged mitochondrial clearance. Dysregulation of NIPSNAP3A has been linked to pathologies such as cancer, neurodegenerative disorders, and metabolic syndromes, though its precise mechanisms remain under investigation.

Antibodies targeting NIPSNAP3A are widely utilized in research to study its expression, localization, and function. They are validated for techniques like Western blotting, immunofluorescence, and immunohistochemistry, often in models of mitochondrial dysfunction or disease. Specificity is confirmed using knockout controls, ensuring recognition of the ~20 kDa protein. Recent studies highlight its potential as a biomarker in cancer, where altered expression correlates with tumor progression. Additionally, NIPSNAP3A antibodies aid in exploring its interaction networks, shedding light on mitochondrial dynamics and disease pathways. Continued research aims to clarify its therapeutic relevance in mitochondrial disorders and age-related conditions.