ANKRD10抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HT-29 and A375 cell lysates, Primary antibody: P02865(ANKRD10 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

The ANKRD10 (Ankyrin Repeat Domain 10) antibody is a tool used to detect and study the ANKRD10 protein, a member of the ankyrin repeat-containing protein family. ANKRD10 is involved in various cellular processes, including cell cycle regulation, signal transduction, and maintaining genomic stability. It interacts with proteins like Polo-like kinase 1 (PLK1), influencing mitotic progression and cytokinesis. Dysregulation of ANKRD10 has been implicated in cancer, with studies suggesting roles as both a tumor suppressor and a potential oncogene depending on context. For example, reduced ANKRD10 expression is linked to hepatocellular carcinoma and breast cancer progression, while its overexpression may promote certain gastrointestinal cancers.

ANKRD10 antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze protein expression, localization, and interactions. These antibodies help researchers explore ANKRD10's tissue-specific functions, its involvement in disease mechanisms, and its potential as a therapeutic target. Commercially available antibodies are typically validated for specificity using knockout cell lines or siRNA knockdown. However, inconsistencies in reported roles of ANKRD10 across studies highlight the need for further research, emphasizing the importance of reliable antibody tools to clarify its biological and pathological significance.