GLYAT抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse kidney tissue and Human kidney tissue lysates, Primary antibody: P02836(GLYAT Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P02836(GLYAT Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of GLYAT Antibody**

GLYAT (glycine-N-acyltransferase) is a liver-enriched enzyme belonging to the acyltransferase family, primarily involved in conjugating glycine with acyl-CoA substrates to form acyl-glycine derivatives. This reaction plays a critical role in detoxifying xenobiotics, particularly benzoic acid derivatives, and endogenous metabolites. GLYAT is localized in mitochondria and contributes to the elimination of toxic acyl groups, linking it to metabolic homeostasis and liver function.

GLYAT antibodies are immunological tools developed to detect and study the expression, localization, and function of the GLYAT protein. These antibodies are essential for applications like Western blotting, immunohistochemistry, and ELISA, enabling researchers to investigate GLYAT's role in physiological and pathological processes. For instance, altered GLYAT activity has been associated with metabolic disorders, drug toxicity, and liver diseases, making its study relevant for understanding disease mechanisms.

The development of specific and high-affinity GLYAT antibodies has facilitated advancements in characterizing its tissue distribution, regulatory mechanisms, and interactions with other detoxification pathways. However, challenges remain, such as ensuring antibody specificity across species and avoiding cross-reactivity with homologous enzymes. Ongoing research aims to refine these tools for diagnostic or therapeutic applications, including targeting metabolic syndromes or enhancing detoxification pathways. Overall, GLYAT antibodies are vital for unraveling the enzyme's biological significance and translational potential.